In larger games say 2k+ I've ran both the spyders and Lychguard. It's a personal preference

The stalker to take down their armor is of course perfect. the twin linking buff it gives works for multiple things though, my preference is the heavy gauss cannon. because once their armor is down, what else do you have to shoot it at and be effective? if your in the 12-24" range what unit are you offering a benefit with the reroll? why not re-roll the scatter on a doomsday? these are all just ideas for you, of always make your army to your own personal preferences and flavor!
and just because i love them, I'll offer one more tidbit to sway you for destroyers. in 6th edition it is rumored that "Preferred Enemy" will work for shooting attacks as well as melee, and destroyers have "preferred enemy: EVERYTHING"
also I don't know what your local opponents like to run but mine are typically either heavy melee with alot of armor, or shooters. my last 2k+ army had the lychguard unit, 2 spyders, and a FW Tomb stalker for melee support, because even if I'm not playing a melee army, these units can take a pounding and if/when they get into combat, they will roll though your average shooter list.